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KMID : 0355420220460020070
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Journal of Korean Academy of Oral Health
2022 Volume.46 No. 2 p.70 ~ p.77
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Lysozyme hydrochloride 0.01%, sodium fluoride 0.02%, cetylpyridinium chloride 0.05% antibacterial and sterilizing effect of mouth freshener
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Park Hye-Won
Cho Ja-Won
Yoo Hyun-Jun
Jeon Yeol-Mae
Shin Kyong-Hoon
Ha Seong-Min
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Abstract
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Objectives: This study aimed to assess the antibacterial, bactericidal, and mouth freshener effects of lysozyme hydrochloride 0.01%, sodium fluoride 0.02%, and cetylpyridinium chloride 0.05%.
Methods: Eight oral disease-related bacteria were cultivated anaerobically. Four samples were prepared with or without 0.5% cetylpyridinium chloride, 0.2% sodium fluoride, and 0.1% lysozyme hydrochloride. Antimicrobial activity was tested in 96-well microplates. After assessing the bacterial count, the bacterial suspension was mixed with samples and spread on agar. The bactericidal rate was calculated by counting and comparing treated and untreated colonies.
Results: Lysozyme hydrochloride 0.01%, sodium fluoride 0.02%, and cetylpyridinium chloride 0.05% mouth fresheners sterilized 99.99% of 8 oral bacteria, including Streprococcus mutans . Lysozyme hydrochloride 0.01%, sodium fluoride 0.02%, and cetylpyridinium chloride 0.05% mouth fresheners showed 99.97% bactericidal activity against Lactobacillus acidophilus.
Conclusions: Lysozyme hydrochloride 0.01%, sodium fluoride 0.02%, and cetylpyridinium chloride 0.05% mouth fresheners confirmed the sterilization and antibacterial effects on oral disease-causing bacteria.
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KEYWORD
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Anti-bacterial agents, Cetylpyridinium chloride, Fluorides, Mouthwashes, Sterilization
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